Machete is a renegade former “Mexican Federale”. He roams the cities, towns, and streets of Texas looking for work after a shakedown from a drug lord called Torrez. Machete has a run-in with Benz, a local businessman and spin doctor, who tells Machete that McLaughlin, a corrupt senator, is sending hundreds of illegal immigrants out of the country and that he must be killed. Benz offers Machete $150,000 to kill McLaughlin who quickly accepts the murder contract. Attempting to assassinate the senator at a political rally, Machete is double-crossed and is shot in the shoulder by Benz’s henchmen who are soon revealed to be in league with Senator McLaughlin who orchestrated the entire attempted assassination with Benz as part of a false flag operation to gain widespread public support for McLaughlin’s harsh anti-immigration laws by setting up Machete as the patsy to make it appear that an outlaw illegal Mexican immigrant tried to assassinate the senator.
Now on the run from the law and being tracked by Sartana, a persistent U.S. Immigration and Customs Enforcement agent with a special interest in the blade slinger, Machete goes after Benz and his men, as well as Senator McLaughlin, with the help of his “holy” Federale-turned-priest brother Padre, a saucy meat cleaver-wielding taco slinger named Luz, and April, a socialite with a penchant for guns. Machete rallies a group of illegal migrants together, and begins to hunt the people who double crossed him.